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2018 Cholesterol Clinical Practice Guidelines Page 21 determine whether de. Grundy SM, et al. 2018 Cholesterol Clinical Practice Guidelines Page 22 LDL-C. 2018 AHA/ACC Cholesterol Guideline. Circulation. 2019;139:e1082–e1143. Four Statin Management Groups. 4. Clinical ASCVD. Primary Prevention. No Diabetes.In patients 40 to 75 years of age with diabetes mellitus and LDL-C ≥70 mg/dL (≥1.8 mmol/L), start moderate-intensity statin therapy without calculating 10- 2018 AHA/ACC/Multi-Society. Cholesterol Treatment Guideline. A Summary by the National Lipid Association. Education and Executive Committees. Disclosures.